Natural Progesterone contraindications.
Progesterone should not be used by women with any of the following conditions:
- Any unexplained or abnormal vaginal bleeding
- History of herpes gestationis, jaundice of pregnancy
- Severe liver disease - cholestatic jaundice, hepatitis, Rotor syndrome or Dubin-Johnson syndrome
- Known sensitivity to progesterone creams or any of their individual components
Reported Side Effects of Progestational Agents
Natural (micronized) progesterone
From http://www.aafp.org/afp/20001015/1839.html (copy and paste this address into your browser address bar).
How to use progesterone cream.
Women differ in almost every aspect of their physiologies. Although genetically all humans are 99 percent the same, that 1 percent difference can account for an astounding variation in how the details work. It’s not rational for a doctor to order the same dose of any given medicine for every patient, and the same is true for natural progesterone.
While medical professionals can give you guidelines to work within, it’s up to you to find the best dose for your body. Ideally, you should be able to find the minimum amount you can use to gain and sustain relief from your symptoms. Because natural progesterone is so safe, it won’t hurt you to use a little more than your optimum dose. That gives you plenty of room for experimentation.
On the other hand, as with most substances, too much progesterone can cause problems. As the use of progesterone has increased in popularity, health care professionals have developed many different schools of thought about how to use it, and many of them prescribe very high doses of progesterone. This practice is counterproductive and leads to further hormone imbalance, not to mention a handful of interesting theories about why the progesterone isn’t working the way Dr. Lee says it does. Here’s the answer, folks: It’s the overdose!
Chronically high doses of progesterone over many months eventually cause progesterone receptors to turn off, reducing its effectiveness. Using excessive doses of progesterone can also cause the side effects listed below. But keep in mind, not all women suffer from these side effects when they use excessive doses of progesterone.
Possible Side Effects Of Excessive Progesterone.
- Lethargy or sleepiness. This is probably an effect of allopreganolone, a by-product of progesterone, on the brain.
- Edema (water retention). This is probably caused by excess conversion to deoxycortisone, a mineralocorticoid made in the adrenal glands that causes water retention.
- Candida. This is the bacterium present in a yeast infection; excess progesterone can inhibit anti-Candida neutrophils (white blood cells).
- Bloating. Excess progesterone slows gastrointestinal (GI) transport, and with the wrong kind of gastrointestinal flora, such as candida, this can lead to bloating and gas. (During pregnancy the high levels of progesterone slow food transport through the GI tract to enhance absorption of nutrients.)
- Lowered libido. Excess progesterone blocks an enzyme called reductase that allows conversion of testosterone to DHT, and thus over inhibits the conversion. This happens primarily to men who are using too much progesterone.
- Mild depression. Excess progesterone down-regulates estrogen receptors, and brain response to estrogens is needed for seratonin production.
- Exacerbated symptoms of estrogen deficiency. Excess progesterone down-regulates estrogen receptors and desensitises tissue to estrogen. Because progesterone receptors are dependent on estrogen in the absence of estrogen can cause a lot of problems, Dr. Zava especially sees this in women who have very low estradiol and are taking large doses of progesterone.